Working in his lab at the University of Colorado Medical School, Theodore was facing a serious issue. Since he successfully cloned HeLa cells in 1955, Theodore Puck had focused his attention on cytogenetic changes, but the high number and large size of human chromosomes didn't make his job any easier. Rodents were already in use in laboratories at that time, but could not help Puck. Mice have forty chromosomes. Rats have forty-two.
With 85 molecules under development and 3 approvals to date, it seems that bispecific antibodies may be the novel therapeutic booming class on the market.
Beyond the mechanistic advantages, bsAbs offer the possibility to combine in one single molecule the potential of two different antibodies without the related cost of two parallel development programs.
But with the victory, comes the flip side of the coin. In fact, a pretty ancient coin.