Delivering unique therapeutic and R&D monoclonal antibodies against membrane receptors and haptens

SYnAbs generates innovative monoclonal antibodies against:

SYnAbs unique technologies (SYnDNA vector, SYnCell syngeneic cell, in-house adjuvant) coupled with its strong expertise in breaking immune tolerance in proprietary rat-LOU species, ensure the generation of high specificity and higher affinity antibodies, benefiting from natural in-vivo maturation and targeting epitopes that are difficult to express in their native and functionally active conformation.

 

The application of such technologies have led, among others, to the generation of numerous functional therapeutic antibodies like : 





Raising antibodies against difficult to express antigens


Generating antibodies against conformation sensitive targets thanks to proprietary DNA, conformational peptide and whole cell immunization technologies


>99% success rate for small and poor immunogenic antigens and highly homologous epitopes


Extreme specificity monoclonal antibodies


Higher affinity monoclonal antibodies


Access to multiple immune repertoires and benefiting from natural in-vivo maturation


Additional epitope recognition in proprietary rat-LOU


Generating highly specific monoclonal antibodies targeting complex transmembrane proteins, chemical drugs, steroids, small and cyclic peptides, neoepitopes, toxins, epigenetic modifications, and carbohydrates, thanks to the unique combination of SynAbs proprietary technologies.

 

"Application of Synabs technologies led to the raising of therapeutic anti-CD2 Siplizumab and its licensing to our company. This successful mAb is now part of AstraZeneca pipeline".

 

"For a project involving the development of innovative immunoassays againt a particular steroid, SynAbs rapidly came to the conclusion that only rat-LOU species could deliver the expected outcomes. This small molecule project has become a huge success for Immunodiagnostic Systems!"

 

"We chose to launch one hard program with SynAbs in order to develop an anti-post translational modifications antibody. Indeed, there was no existing available monoclonal antibody for that given modification as of today. We are delighted with the collaboration with Synabs! We got a purified antibody with a high specificity to the very methyl group ! They know what they are talking about and have considerable experience with antibody production. They are also very flexible and the communication flow is efficient as well.  As this program is a success, VolitionRx has initiated new ones"

 

"Kinetic and functional assays with Synabs rat mAbs in comparison to the best commercial mouse mAb anti-Valproic acid reference were conducted by Werfen. All rat mAbs demonstrate a better affinity compared to mouse mAb, a dose-response curve contrary to mouse mAb. SynAbs Clone#30 has the highest affinity for free Valproic Acid (lowest IC50 - 3.5µM) of the market!"

 


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A flexible, cost-effective platform developed for the discovery of novel compounds (protein degraders)