Lipid monoclonal antibodies

Lipids can be divided into three major groups:

 

- triglycerides or fats

- phospholipids

- steroids.

 

Steroid or steroid hormone, is the generic name for sterol-derived hormones, secreted by the endocrine glands (adrenal cortex, testes, ovaries and placenta).

 

Steroid hormones can be classified into 3 major groups according to the basic skeletons:

 

(1) the estrane group, from which estrone or folliculin are derived, and estrogens;

(2) the androstane group, from which testosterone and androgens are derived;

(3) the group of pregnane, from which progesterone, progestins and corticosteroids derived from mineralocorticoids and glucocorticoids.

 

To generate a monoclonal antibody against fat, phospholipid and steroid is a very tricky performance as lipids are typical hapten molecules. Furthermore anti-lipid antibodies may react against proteins or molecules that bind to lipid type particles. 

 

Only a very few antibodies that have the affinity to bind against lipids are available on the market. SYnAbs antibodies are part of them. 


Achievements

Different high affinity mAbs have been synthesized with success by SYnAbs team and are now part of blockbusters molecules of our clients. 

 

Some examples of SYnAbs mAb anti-lipids generation:

  • anti-T3 (triiodothyronine) monoclonal antibody that doesn't cross-react with T4 (thyroxine)
  • anti-DHT (dihydrotestosterone) mAb that doesn't cross-react with free testosterone

Testimony

"As a leading in-vitro diagnostic provider to the clinical laboratory market, IDS is compelled to continuously rely on strong preferred partners who commit to high quality standards. For a project involving the development of innovative immunoassays againt a particular steroid, SynAbs rapidly came to the conclusion that only rat-LOU species could deliver the expected outcomes. This small molecule project has become a huge success !"

 

Mhammed Bougoussa,

Immunodiagnostic Systems,

R&D Manager