Testosterone is converted to DHT by 5-alpha reductase. DHT is the active metabolite of testosterone in the urogenital sinus. Most of the circulating DHT concentrations represent the androgen converter (testosterone, androstenedione, DHA and SDHA).
The determination of DHT is of interest in the exploration of hirsutism, especially idiopathic hirsutism in which the concentrations can be increased. Values are very low in 5-alpha reductase deficiency, which are manifested in boys by male pseudo-hermaphroditism at birth.
SYnAbs has first developed a guinea pig monoclonal antibody targeting dihydrotestosterone.
Description: guinea pig anti-dihydrotestosterone
Cross-reactivity: doesn't bind free testosterone
Rue Auguste Piccard, 48
I-Tech Incubator 2