Synabs launches anti-pan-SERPin and anti-SERPinA monoclonal antibodies. 3,000 members. Complicated family reunions to organize. And unfortunately, not as famous as the Kardashians. Meet the SERPin family and SYnabs unique products.
The microbiome is central to human health, and early-life gut microbiota has a profound implication on shaping our immune system, especially at the prenatal or neonatal stages.
Since the discovery of the microbiome, many scientists have questioned both the mother-to-infant bacterial transmission process and microbiome evolution during the very first years of our lives.
Is the prenatal or the postnatal period the most critical phase for the development of microbiota composition?
Working in his lab at the University of Colorado Medical School, Theodore was facing a serious issue. Since he successfully cloned HeLa cells in 1955, Theodore Puck had focused his attention on cytogenetic changes, but the high number and large size of human chromosomes didn't make his job any easier. Rodents were already in use in laboratories at that time, but could not help Puck. Mice have forty chromosomes. Rats have forty-two.
The interaction between cancer and bacteria is not new.
As early as 1868, Busch began infecting sarcoma patients with erysipelas. This experiment was a semi-success in sofar as the reduction of the tumors was quickly followed by a reappearance of the cancer. In 1891, Coley pursued Busch's work and injected a throat cancer patient with Streptococcus erysipelas cultures: this time, the patient returned to a healthy condition for eight years.
735 autopsy reports.
Report after report, the conviction of Stephen was growing. What he was observing could not have happened by chance.
This time, he was sure. A pattern was emerging.
His hypothesis was finally confirmed. His father James had been a successful surgeon, founder of the modern scientific pathology, but his discovery could make him even more famous. The impact of what he had in front of him was far greater.
He picked up his stylograph, look at the date on the
“Huge opportunities”. “Many hurdles”. “Enormous potential”.
It's just an excerpt of the several terms you'll come across if you search for them on the web.
What am I talking about?
Exosomes. Also referred to as Prostasomes, Tolerosomes, Dexosomes, or Nanovesicles.
Markers of cancer diseases, the basis of broad diagnostic platform, and potential future therapeutics, exosomes have now surpassed 2,000 annual scientific publications.
But why are exosomes so unique?
Adeno-associated virus (AAV) is a small and single strand DNA virus. In 1960, this non-enveloped entity was accidentally discovered in adenovirus culture. It was before we understood that AAV requires the presence of another "helper" virus in order to propagate. This family was named as “Dependovirus genus”.
The genome of SARS-CoV-2 counts 29,811 nucleotides, encoding for 29 different proteins. The translation of the linear single stranded RNA conducts to the generation of the following proteome:
4 are structural proteins, S, N, M and E
16 proteins are non-structural proteins or NSP: the first 11 are encoded in ORF1a whereas the last 5 are encoded in ORF1b
9 are accessory proteins named ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF9c and ORF10.
With more than 3,000,000 cases and 200,000 deaths, and after three months of worldwide outbreak, scientists keep on learning about COVID-19 every day.
How can people be positively diagnosed twice to COVID? Are serological diagnostic tests 100% reliable? Which part of the population is more likely to be infected?
Let’s review the latest updates on what we know about this challenging virus, and the on-going assay developments.