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About SYnAbs


Innovative mAbs against poor immunogenic compounds and complex antigens

 

SYnAbs' vision is to fill the gap on the marketplace for innovative monoclonal antibodies against poor immunogenic compounds and complex antigens. Targeting steroids, peptides, small molecules, toxins, lipids and polysaccharides (on fungi and bacteria), SYnAbs has developed a strong expertise in immunology to break immunotolerance in rat and guinea pig species to generate unique monoclonal antibodies of extreme specificity and higher affinity.

 

Custom manufacturing of antibodies

 

SYnAbs was set up in September 2015 out of Professor Pierre Gianello’s experimental surgery laboratory (CHEX) in order to develop greater expertise in the custom production of monoclonal antibodies, of rats but also of guinea pigs. The UCL spin-off was set up as a result of coordinated action by the laboratory, the Louvain Technology Transfer Office (LTTO), Wallonia Biotech Coaching and a French group, Biotech Investissement (which owns RD Biotech and Diaclone companies).

 

Unique monoclonal antibodies

 

The unique expertise of SYnAbs team has allow us to generate unique monoclonal antibodies on the marketplace, bringing added value in the fields of hormones, toxins, auto-immune diseases and oncology. You'll find here a few examples.

guinea pig anti-dihydrotestosterone

Uniqueness features:

  • Higher affinity compared to other species
  • Only mAb of guinea pig species on the market

Description: guinea pig anti-dihydrotestosterone

Class: monoclonal

Type: primary 

Host/Isotype : guinea pig

 

IgG2a kappa rat anti-VHH

 Uniqueness features:

  • Only reference that can detect the 7 families of VHH

Description: IgG2a kappa rat anti-VHH

Class: monoclonal

Type: secondary 

Host/Isotype : rat

 

IgG2b kappa rat anti-His tag (N-ter & C-ter)

Uniqueness features:

  • Reference validated on 17 different recombinant proteins
  • Detect both N-terminal & C-terminal sequences

Description: IgG2b kappa rat anti-His Tag

Class: monoclonal

Type: primary 

IgG1 rat anti-human IgG4

Uniqueness features:

  • No-cross reactivity with other human isotypes
  • No paratope hiding when labelled with HRP

Description: rat anti-human IgG4

Class: monoclonal

Type: secondary

 

 

IgG1 kappa rat anti-dinitrophenyl hapten

Uniqueness features: 

  • Best reference to detect DNP on DNA, RNA...
  • Advantageously replaces biotin-streptavidin
  • Best sales in USA

Description: IgG1 kappa rat anti-dinitrophenyl hapten

Class: monoclonal 

Type: primary, irrelevant

 

Innovative primary monoclonal antibodies

 

As part of custom services, SynAbs is developing unique off-the-shelf references.

 

SynAbs catalog of monoclonals antibodies include:

Large catalogue of secondary antibodies

 

 SYnAbs SA is currently involved in the production of rat monoclonal antibodies, serving CROs (mAb and custom immunoassays) and with a large catalogue of secondary monoclonal antibodies (more than a hundred secondary anti-immunoglobulins) and unique primary monoclonal antibodies has gained strong international recognition which its founders wish to increase further.

 

Thanks to its scientists led by their CSO Yannick Nizet, PhD, as well as the broad biotechnology support offered by its sister companies RD-Biotech and Diaclone, France, SynAbs can indeed present a one-stop-shop portfolio of services, covering the antigen synthesis and the hapten-carriers chemistry, through the parallel immunisation of mice, rats and guinea pigs, up to the custom generation and manufacturing of gram levels of these mouse, rat and guinea pigs monoclonal antibodies.

 

This unique triple immunisation platform enables SynAbs to increase the probability getting the unique monoclonal you’re looking for, and therefore maximizes the success rate of our clients !