Innovative
Monoclonal Antibodies
Against Small Molecules
& Transmembrane Proteins

Therapeutic Treg depleting CCR8 - GPCR chemokine receptor - antibodies

hCCR8 expression on HuT-78 cell line

In black : GAM AF488. Mean Fluorescence 3300
In red: mAb Biolegend + GAM AF488. Mean Fluorescence 13700
In blue: SynCCR8 + GAM AF488. Mean Fluorescence 48300

Affinity comparison between BioLegend anti-CCR8 and SYnAbs MA-CCR8 on HuT-78

In blue: SynAbs anti-CCR8 antibody
In red: BioLegend anti-CCR8 antibody
Labelling: Biolegend or SynCCR8 + GAM AF488

Blocking of MA-CCR8 on CCL1 binding on HuT-78

In black: negative control mean fluorescence 2600
In red: CCL1 AF647 mean fluorescence 5900
In brown: MA-CCR8 + CCL1 AF647 mean fluorescence 2700

Do you want to know more about SYnAbs therapeutic anti-human CCR8 and test its potential as Treg depletion agent for immuno-oncology indications?