Neoepitopes are peptides, located on neoantigens, that arise from mutations and recognized as different from self and presented by antigen-presenting cells (APCs), such as dendritic cells (DCs) and the tumor cells itself.
Neo-epitopes can also be created by covalent post-translational modifications like enzyme cleavage process.
The neoepitopes, specifically reactivating T cells, are particularly interesting in immune escape situations after checkpoint inhibitors treatments now considered standard treatments. They are also hugely studied in the context of the creation of new vaccine strategies.
Different high affinity mAbs have been synthesized with success by SYnAbs team and are now part of blockbusters molecules of our clients.
Some examples of SYnAbs mAb anti-neoepitopes generation: